Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic
Identifieur interne : 000460 ( Main/Exploration ); précédent : 000459; suivant : 000461Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic
Auteurs : Gudrun S. Freidl ; Henk-Jan Van Den Ham ; Maciej F. Boni [Viêt Nam, Royaume-Uni] ; Erwin De Bruin ; Marion P. G. KoopmansSource :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Seropositivity to avian influenza (AI) via low-level antibody titers has been reported in the general population and poultry-exposed individuals, raising the question whether these findings reflect true infection with AI or cross-reactivity. Here we investigated serological profiles against human and avian influenza viruses in the general population using a protein microarray platform. We hypothesized that higher antibody diversity across recent H1 and H3 influenza viruses would be associated with heterosubtypic reactivity to older pandemic- and AI viruses. We found significant heterogeneity in antibody profiles. Increased antibody diversity to seasonal influenza viruses was associated with low-level heterosubtypic antibodies to H9 and H7, but not to H5 AI virus. Individuals exposed to the recent 2009 A(H1N1) pandemic showed higher heterosubtypic reactivity. We show that there is a complex interplay between prior exposures to seasonal and recent pandemic influenza viruses and the development of heterosubtypic antibody reactivity to animal influenza viruses.
Url:
DOI: 10.1038/srep20385
PubMed: 26853924
PubMed Central: 4745054
Affiliations:
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Freidl</name><affiliation><nlm:aff id="a1"><institution>Viroscience Department, Erasmus Medical Center</institution>, Rotterdam,<country>the Netherlands</country></nlm:aff><wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry></affiliation><affiliation><nlm:aff id="a2"><institution>Virology Department, Centre for Infectious Diseases Research, Diagnostics and Screening, National Institute for Public Health and the Environment</institution>, Bilthoven,<country>the Netherlands</country></nlm:aff><wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Van Den Ham, Henk Jan" sort="Van Den Ham, Henk Jan" uniqKey="Van Den Ham H" first="Henk-Jan" last="Van Den Ham">Henk-Jan Van Den Ham</name><affiliation><nlm:aff id="a1"><institution>Viroscience Department, Erasmus Medical Center</institution>, Rotterdam,<country>the Netherlands</country></nlm:aff><wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Boni, Maciej F" sort="Boni, Maciej F" uniqKey="Boni M" first="Maciej F." last="Boni">Maciej F. Boni</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme</institution>, Ho Chi Minh City,<country>Vietnam</country></nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford</institution>, Oxford,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Bruin, Erwin" sort="De Bruin, Erwin" uniqKey="De Bruin E" first="Erwin" last="De Bruin">Erwin De Bruin</name><affiliation><nlm:aff id="a1"><institution>Viroscience Department, Erasmus Medical Center</institution>, Rotterdam,<country>the Netherlands</country></nlm:aff><wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry></affiliation><affiliation><nlm:aff id="a2"><institution>Virology Department, Centre for Infectious Diseases Research, Diagnostics and Screening, National Institute for Public Health and the Environment</institution>, Bilthoven,<country>the Netherlands</country></nlm:aff><wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name><affiliation><nlm:aff id="a1"><institution>Viroscience Department, Erasmus Medical Center</institution>, Rotterdam,<country>the Netherlands</country></nlm:aff><wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry></affiliation><affiliation><nlm:aff id="a2"><institution>Virology Department, Centre for Infectious Diseases Research, Diagnostics and Screening, National Institute for Public Health and the Environment</institution>, Bilthoven,<country>the Netherlands</country></nlm:aff><wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Seropositivity to avian influenza (AI) via low-level antibody titers has been reported in the general population and poultry-exposed individuals, raising the question whether these findings reflect true infection with AI or cross-reactivity. Here we investigated serological profiles against human and avian influenza viruses in the general population using a protein microarray platform. We hypothesized that higher antibody diversity across recent H1 and H3 influenza viruses would be associated with heterosubtypic reactivity to older pandemic- and AI viruses. We found significant heterogeneity in antibody profiles. Increased antibody diversity to seasonal influenza viruses was associated with low-level heterosubtypic antibodies to H9 and H7, but not to H5 AI virus. Individuals exposed to the recent 2009 A(H1N1) pandemic showed higher heterosubtypic reactivity. We show that there is a complex interplay between prior exposures to seasonal and recent pandemic influenza viruses and the development of heterosubtypic antibody reactivity to animal influenza viruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Couch, R B" uniqKey="Couch R">R. B. 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Laurie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, J K" uniqKey="Nelson J">J. K. Nelson</name></author><author><name sortKey="Shields, M D" uniqKey="Shields M">M. D. Shields</name></author><author><name sortKey="Stewart, M C" uniqKey="Stewart M">M. C. Stewart</name></author><author><name sortKey="Coyle, P V" uniqKey="Coyle P">P. V. Coyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Revelle, W" uniqKey="Revelle W">W. Revelle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wickam, H" uniqKey="Wickam H">H. Wickam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Venables, W N" uniqKey="Venables W">W. N. Venables</name></author><author><name sortKey="Ripley, B D" uniqKey="Ripley B">B. D. Ripley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, J" uniqKey="Fox J">J. Fox</name></author><author><name sortKey="Weisberg, S" uniqKey="Weisberg S">S. Weisberg</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li><li>Viêt Nam</li></country></list><tree><noCountry><name sortKey="De Bruin, Erwin" sort="De Bruin, Erwin" uniqKey="De Bruin E" first="Erwin" last="De Bruin">Erwin De Bruin</name><name sortKey="Freidl, Gudrun S" sort="Freidl, Gudrun S" uniqKey="Freidl G" first="Gudrun S." last="Freidl">Gudrun S. Freidl</name><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name><name sortKey="Van Den Ham, Henk Jan" sort="Van Den Ham, Henk Jan" uniqKey="Van Den Ham H" first="Henk-Jan" last="Van Den Ham">Henk-Jan Van Den Ham</name></noCountry><country name="Viêt Nam"><noRegion><name sortKey="Boni, Maciej F" sort="Boni, Maciej F" uniqKey="Boni M" first="Maciej F." last="Boni">Maciej F. Boni</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Boni, Maciej F" sort="Boni, Maciej F" uniqKey="Boni M" first="Maciej F." last="Boni">Maciej F. Boni</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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